riether lab

Group Riether

Publications

Original Articles

2024

• Rubino, V., Hüppi, M., Höpner, S., Tortola, L., Schn&uuriger, N., Legenne, H., Taylor, L., Voggensperger, S., Keller, I., Bruggmann, R., Kronig, M.N., Bacher, U, Kopf, M., Ochsenbein, A.F. and Riether C. . 2024. IL21/IL21R signaling renders acute myeloid leukemia stem cells more susceptible to cytarabine treatment and CAR T cell therapy.
  Cell Reports Medicine.
  PubMED

2023

• Näf, P., Radpour, R., Ruckstuhl, C., Bodmer, N., Baerlocher, G.M., Döhner, H., Döhner, K., Riether C., and Ochsenbein, A.F.. 2023. IL-33-ST2 signaling promotes stemness in subtypes of myeloid leukemia cells through the Wnt and Notch pathways.
  Science Signaling.
  PubMED

2022

• Riether, C.. 2022. Regulation of hematopoietic and leukemia stem cells by regulatory T cells.
  Frontiers in Immunology.
  PubMED
• Bührer, E.D., Amrein, M.A., Forster, S., Isringhausen, S., Schurch, C.M., Bhate, S.S., Brodie, T., Zindel, J., Stroka, D., Al-Sayed, M., Nombela-Arrieta, C., Radpour, R., Riether C., and Ochsenbein, A.F. 2022. Splenic red pulp macrophages provide a niche for CML stem cells and induce therapy resistance.
  Leukemia.
  PubMED
• Deng, H., Gao, Y., Trappetti, V., Hertig, D., Karatkevich, D., Losmanova, T., Urzi, C., Ge, H., Geest, G.A., Bruggmann, R., Djonov, V., Nuoffer, J.M., Vermathen,P., Zamboni, N., Riether, C., Ochsenbein, A.F., Peng, R.W., Kocher, G.J., Schmid, R.A., Dorn. P. and Marti. T.M. 2022. Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing mtDNA damage.
  Cellular and Molecular Life Sciences.
  PubMED
• Flieswasser, T., Van den Eynde, A., Van Audenaerde, J., De Waele, J., Lardon, F., Riether, C., de Haard, H., Smits, E., Pauwels, P. amd Jacobs, J. 2022. The CD70-CD27 axis in oncology: the new kids on the block..
  J Exp Clin Cancer Res.
  PubMED

2021

• Hinterbrandner, M., Rubino, V., Stoll, C., Forster, S., Schnüriger, N., Radpour, R., Baerlocher, G.M., Ochsenbein, A.F., and Riether, C. 2021. Tnfrsf4-expressing regulatory T cells promote immune escape of chronic myeloid leukemia stem cells.
  JCI Insight.
  PubMED
• Radpour, R., Stucki, M., Riether, C. and Ochsenbein, A.F. 2021. Epigenetic silencing of immune-checkpoint receptors in bone marrow- infiltrating T cells in acute myeloid leukemia.
  Frontiers in Oncology.
  PubMED
• Ruzgys, P., Böhringer, S., Dokumaci, A., Hari, Y., Schürch, C.M., Brühl, F., Schürch, S., Szidat, S., Riether, C., Satkauskas, S., Geiser, T., Hradetzky, D. and Gazdhar, A. 2021. Electrospray mediated localized and targeted chemotherapy in a mouse model of lung cancer.
  Frontiers in Pharmacology.
  PubMED
• Germic, N., Hosseini, A., Stojkov, D., Obersonn, K., Claus, M., Benarafa, C., Calzavarini, S., Angelillo-Scherrer, A., Arnold, I.C., Müler, Riether, C. Yousefi, S. and Simon, H.U. 2021. ATG5 promotes eosinopoiesis, but inhibits eosinophil effector functions.
  Blood.
  PubMED
• Höpner, S., Raykova, A., Radpour, R., Amrein, M., Koller, D., Baerlocher, G.M., Riether, C. and Ochsenbein, A.F. 2021. LIGHT/LTBR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells.
  Nature Communications.
  PubMED
• Riether C., Radpour R., Kallen N.M., Bürgin D. T., Bachmann, C., Schürch, C.M., Lüthi, U., Armabasic M., Hoppe, S., Albers, C.E., Baerlocher, G.M. and Ochsenbein, A.F. 2021. Metoclopramide treatment blocks CD93-signaling mediated self-renewal of chronic myeloid leukemia stem cells.
  Cell Reports.
  PubMED

2020

• Amrein M.A., Bührer E.D., Amrein M.L., Li Q., Rothschild S., Riether C., Jaggi R., Savic-Prince, Bubendorf L., Gautschi O.and Ochsenbein, A.F. 2020. Chemotherapy negatively impacts the tumor immune microenvironment in NSCLC: an analysis of pre- and post-treatment biopsies in the multi-center SAKK19/09 study.
  Cancer Immunol Immunother.
  PubMED
• Brigger D., Riether C., van Brummelen R., Mosher K.I., Shiu A., Ding Z., Zbämren N., Gasser P., Guntern P., Yousef H., Castellano J.M., Storni F., Graff-Radford N., Britschgi M., Grandgirard D., Hinterbrandner M., Siegrist M., Moullan N., Hofstetter W., Leib S.L., Villiger P.M., Auwerx J., Villeda S.A., Wyss-Coray T., Noti M. and Eggel A. 2020. Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age.
  Nature Metabolism.
  PubMED
• Riether C., Pabst T., Höpner S., Bacher U., Hinterbrandner M., Banz Y., Müller R., Manz M. G., Gharib W. H., Francisco D., Bruggmann R., van Rompaey L., Moshir M., Delahaye T., Gandini D., Erzeel E., Hultberg A., Fung S., de Haard H., Leupin N., and Ochsenbein, A.F. 2020. Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents.
  Nature Medicine.
  PubMED
• Frangez Z., Fernandez-Marrero Y., Stojkov D., Seyed Jafari S.M., Hunger R.E., Djonov V., Riether C., Simon H.U. 2020. BIF-1 Inhibits Both Mitochondrial and Glycolytic ATP Production: Its Downregulation Promotes Melanoma Growth.
  Oncogene.
  PubMED
• Riether C. and Ochsenbein, A.F. 2020. Genetic Alterations Impact Immune Microenvironment Interactions in Follicular Lymphoma.
  Cancer Cell.
  PubMED
• Jaeger-Ruckstuhl C.A., Hinterbrandner M., Höpner S., Correnti C.E., Lüthi U., Friedli O., Freigang S., Al Sayed M.F., Bührer E.D., Amrein M.A., Schürch C.M., Radpour R., Riether C. and Ochsenbein, A.F. 2020. TNIK signaling imprints CD8+ T cell memory formation early after priming.
  Nature Communications.
  PubMED
• Liu H., He Z., Germic N., Ademi H., Frangez Z., Felser A., Peng S., Riether C., Djonov V., Nuoffer J.M., Bovet C., Mlinaric-Rascan I., Zlobec I., Fiedler M., Perren A., Simon H.U. 2020. ATG12 deficiency leads to tumor cell oncosis owing to diminished mitochondrial biogenesis and reduced cellular bioenergetics.
  Cell Death Differ.
  PubMED

2019

• Radpour, R., Riether, C., Simillion, C., Höpner, S., Bruggmann, R., and Ochsenbein, A.F. 2019. CD8+ T cells expand stem and progenitor cells in favorable but not adverse risk acute myeloid leukemia.
  Leukemia.
  PubMED
• Mohsen, M.O., Heath, M.D., Cabral-Miranda, G., Lipp, C., Zeltins, A., Sande, M., Stein, J.V., Riether, C., Roesti, E., Zha, L., Engeroff, P., El-Turabi, A., Kundig, T.M., Vogel, M., Skinner, M.A., Speiser, D.E., Knuth, A., Kramer, M.F., Bachmann, M.F. 2019. Vaccination with nanoparticles combined with micro-adjuvants protects against cancer.
  J Immunother Cancer.
  PubMED
• Mohsen, M.O., Vogel, M., Riether, C., Muller, J., Salatino, S., Ternette, N., Gomes, A.C., Cabral-Miranda, G., El-Turabi, A., Ruedl, C., Kundig, T.M., Dermime, S., Knuth, A., Speiser, D.E., Bachmann, M.F. 2019. Targeting Mutated Plus Germline Epitopes Confers Pre-clinical Efficacy of an Instantly Formulated Cancer Nano-Vaccine.
  Front Immunol.
  PubMED
• Liu, H., He, Z., Germič, N., Ademi, H., Frangež, Ž., Felser, A., Peng, S., Riether, C., Djonov, V., Nuoffer, J.M., Bovet, C., Mlinarič-Raščan, I., Zlobec, I., Fiedler, M., Perren, A., Simon, H.U. 2019. ATG12 deficiency leads to tumor cell oncosis owing to diminished mitochondrial biogenesis and reduced cellular bioenergetics.
  Cell Death Differ.
  PubMED
• Salomé, B., Gomez-Cadena, A., Loyon, R., Suffiotti, M., Salvestrini, V., Wyss, T., Vanoni, G., Ruan, D.F., Rossi, M., Tozzo, A., Tentorio, P., Bruni, E., Riether, C., Jacobsen, E.M., Jandus, P., Conrad, C., Hoenig, M., Schulz, A., Michaud, K., Della Porta, M.G., Salvatore, S., Ho, P.C., Gfeller, D., Ochsenbein, A., Mavilio, D., Curti, A., Marcenaro, E., Steinle, A., Horowitz, A., Romero, P., Trabanelli, S., Jandus, C. 2019. CD56 as a marker of an ILC1-like population with NK cell properties that is functionally impaired in AML.
  Blood Adv.
  PubMED

2018

• Hensel, J., Wetterwald, A., Temanni, R., Keller, I., Riether, C., van der Pluijm, G., Cecchini, M.G. and Thalmann, G.N. 2018. Osteolytic cancer cells induce vascular/axon guidance processes in the bone/bone marrow stroma.
  Oncotarget.
  PubMED
• Xu, D., Liang, S., Yang, H., Keller, I., Riether, C., Berezowska, S., Marti, T.M., Hall, S.R.R., Bruggmann, R., Kocher, G.J., Schmid, R.A. and Peng, R.W. 2018. Increased sensitivity to apoptosis upon endoplasmic reticulum stress-induced activation of the unfolded protein response in chemotherapy-resistant malignant pleural mesothelioma.
  British Journal of Cancer.
  PubMED
• Liang, S., Bührer, E.D., Berezowska, S., Thomas M.M., Xu, D., Froment, L., Yang, H., Hall, S.R.R, Vassella, E., Yang, Z., Kocher, G.J., Amrein, M.A., Riether, C., Ochsenbein, A.F., Schmid, R.A. and Peng, R. 2018. mTOR mediates a mechanism of resistance to chemotherapy and defines a rational combination strategy to treat KRAS-mutant lung cancer.
  Oncogene.
  PubMED
• AL-Sayed, M., Amrein, M.A., Bührer, E.D., Huguenin, A.L., Radpour, R., Riether, C. and Ochsenbein, A.F. 2018. T-cell-secreted TNF-alpha induces emergency myelopoiesis and myeloid-derived suppressor cell-differentiation in cancer.
  Cancer Research.
  PubMED
• Tièche, C.C., Bührer, E.D., Gao1, Y., Hobi, N., Berezowska, S.A., Wyler, K., Froment, L., Weis, S., Peng, R., Bruggmann, R., Schär, P., Amrein, M.A.,, Hall, S.R.R., Dorn1, P., Kocher1, G., Riether, C., Ochsenbein, A., Schmid1, R.A., Marti1, T.M. 2018. Tumor initiation capacity and therapy resistance are differential features of EMT-related subpopulations in the NSCLC cell line A549.
  Neoplasia.
  PubMED

2017

• Hilmenyuk, T., Ruckstuhl, C.A., Hayoz, M., Berchtold, C., Nuoffer, J.M., Solanki,S., Keun, H.C., Beavis, P.A. , Riether, C., and Ochsenbein, A.F. 2017. T cell inhibitory mechanisms in a model of aggressive Non-Hodgkin's Lymphoma.
  Oncoimmunology.
  PubMED
• Riether, C., Schurch, C.M., Bührer, E.D., Hinterbradner, M., Huguenin, A., Hoepner, S., Zlobec, I., Pabst, T., Radpour, R., and Ochsenbein, A.F. 2017. CD70/CD27 signaling promotes blast stemness and is a viable therapeutic target in acute myeloid leukemia.
  The Journal of Experimental Medicne 214(2):359-380.
  PubMED
• Murone, M., Radpour, R., Attinger, A., Vaslin Chessex, A., Huguenin, A.L., Schurch, C.M., Banz, Y., Sengupta, S., Aguet, M., Rigotti, S., and Riether, C.. 2017. The multi-kinase inhibitor Debio 0617B reduces maintenance and self-renewal of primary human AML CD34+ stem/progenitor cells.
  Molecular Cancer Therapeutics.
  PubMED
• Al Sayed, M.F., Ruckstuhl, C.A., Hilmenyuk, T., Claus, C., Bourquin, J.P., Bornhauser, B.C., Radpour, R., Riether, C., and Ochsenbein, A.F. 2017. CD70 reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies.
  Blood 130:297-309.
  PubMED

2016

Zysset, D., Weber, B., Rihs, S., Brasseit, J., Freigang, S., Riether, C., Banz, Y., Cerwenka, A., Simillion, C., Marques-Vidal, P., et al. 2016. TREM-1 links dyslipidemia to inflammation and lipid deposition in atherosclerosis.
Nature communications 7:13151.
PubMED

2015

• Trabanelli, S., Curti, A., Lecciso, M., Salome, B., Riether, C., Ochsenbein, A., Romero, P., and Jandus, C. 2015. CD127+ innate lymphoid cells are dysregulated in treatment naive acute myeloid leukemia patients at diagnosis.
  Haematologica 100:e257-260.
  PubMED
• Riether, C., Schurch, C.M., Flury, C., Hinterbrandner, M., Druck, L., Huguenin, A.L., Baerlocher, G.M., Radpour, R., and Ochsenbein, A.F. 2015. Tyrosine kinase inhibitor-induced CD70 expression mediates drug resistance in leukemia stem cells by activating Wnt signaling.
  Science translational medicine 7:298ra119.
• Riether, C., Gschwend, T., Huguenin, A.L., Schurch, C.M., and Ochsenbein, A.F. 2015. Blocking programmed cell death 1 in combination with adoptive cytotoxic T-cell transfer eradicates chronic myelogenous leukemia stem cells.
  Leukemia 29:1781-1785.
  PubMED
• Mager, L.F., Riether, C., Schurch, C.M., Banz, Y., Wasmer, M.H., Stuber, R., Theocharides, A.P., Li, X., Xia, Y., Saito, H., et al. 2015. IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms.
  The Journal of clinical investigation 125:2579-2591.
  PubMED

2014

• Weber, B., Schuster, S., Zysset, D., Rihs, S., Dickgreber, N., Schurch, C., Riether, C., Siegrist, M., Schneider, C., Pawelski, H., et al. 2014. TREM-1 deficiency can attenuate disease severity without affecting pathogen clearance.
  PLoS pathogens 10:e1003900.
  PubMED
• Schurch, C.M., Riether, C., and Ochsenbein, A.F. 2014. Cytotoxic CD8+ T cells stimulate hematopoietic progenitors by promoting cytokine release from bone marrow mesenchymal stromal cells.
  Cell stem cell 14:460-472.
  PubMED

2013

• Schurch, C., Riether, C., Amrein, M.A., and Ochsenbein, A.F. 2013. Cytotoxic T cells induce proliferation of chronic myeloid leukemia stem cells by secreting interferon-gamma.
  The Journal of experimental medicine 210:605-621.
  PubMED
• Pacheco-Lopez, G., Doenlen, R., Krugel, U., Arnold, M., Wirth, T., Riether, C., Engler, A., Niemi, M.B., Christians, U., Engler, H., et al. 2013. Neurobehavioural activation during peripheral immunosuppression.
  The international journal of neuropsychopharmacology 16:137-149.
  PubMED

2012

• Schurch, C., Riether, C., Matter, M.S., Tzankov, A., and Ochsenbein, A.F. 2012. CD27 signaling on chronic myelogenous leukemia stem cells activates Wnt target genes and promotes disease progression.
  The Journal of clinical investigation 122:624-638.
  PubMED
• Krstic, D., Madhusudan, A., Doehner, J., Vogel, P., Notter, T., Imhof, C., Manalastas, A., Hilfiker, M., Pfister, S., Schwerdel, C., et al. 2012. Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice.
  Journal of neuroinflammation 9:151.
  PubMED
• Gola, H., Engler, H., Schauer, M., Adenauer, H., Riether, C., Kolassa, S., Elbert, T., and Kolassa, I.T. 2012. Victims of rape show increased cortisol responses to trauma reminders: a study in individuals with war- and torture-related PTSD.
  Psychoneuroendocrinology 37:213-220.
  PubMED
• Claus, C., Riether, C., Schurch, C., Matter, M.S., Hilmenyuk, T., and Ochsenbein, A.F. 2012. CD27 signaling increases the frequency of regulatory T cells and promotes tumor growth.
  Cancer research 72:3664-3676.
  PubMED

2011

• Sommershof, A., Basler, M., Riether, C., Engler, H., and Groettrup, M. 2011. Attenuation of the cytotoxic T lymphocyte response to lymphocytic choriomeningitis virus in mice subjected to chronic social stress.
  Brain, behavior, and immunity 25:340-348.
  PubMED
• Riether, C., Kavelaars, A., Wirth, T., Pacheco-Lopez, G., Doenlen, R., Willemen, H., Heijnen, C.J., Schedlowski, M., and Engler, H. 2011. Stimulation of beta(2)-adrenergic receptors inhibits calcineurin activity in CD4(+) T cells via PKA-AKAP interaction.
  Brain, behavior, and immunity 25:59-66.
  PubMED
• Engler, H., Doenlen, R., Engler, A., Riether, C., Prager, G., Niemi, M.B., Pacheco-Lopez, G., Krugel, U., and Schedlowski, M. 2011. Acute amygdaloid response to systemic inflammation.
  Brain, behavior, and immunity 25:1384-1392.
  PubMED
• Doenlen, R., Krugel, U., Wirth, T., Riether, C., Engler, A., Prager, G., Engler, H., Schedlowski, M., and Pacheco-Lopez, G. 2011. Electrical activity in rat cortico-limbic structures after single or repeated administration of lipopolysaccharide or staphylococcal enterotoxin B. Proceedings.
  Biological sciences 278:1864-1872.
  PubMED

2010

• Engler, H., Doenlen, R., Riether, C., Engler, A., Besedovsky, H.O., Del Rey, A., Pacheco-Lopez, G., and Schedlowski, M. 2010. Chemical destruction of brain noradrenergic neurons affects splenic cytokine production.
  Journal of neuroimmunology 219:75-80.
  PubMED

2009

• Pacheco-Lopez, G., Riether, C., Doenlen, R., Engler, H., Niemi, M.B., Engler, A., Kavelaars, A., Heijnen, C.J., and Schedlowski, M. 2009. Calcineurin inhibition in splenocytes induced by pavlovian conditioning.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 23:1161-1167.
  PubMED
• Koessler, S., Engler, H., Riether, C., and Kissler, J. 2009. No retrieval-induced forgetting under stress.
  Psychological science 20:1356-1363.
  PubMED
• Engler, H., Doenlen, R., Riether, C., Engler, A., Niemi, M.B., Besedovsky, H.O., del Rey, A., Pacheco-Lopez, G., Feldon, J., and Schedlowski, M. 2009. Time-dependent alterations of peripheral immune parameters after nigrostriatal dopamine depletion in a rat model of Parkinson's disease.
  Brain, behavior, and immunity 23:518-526.
  PubMED
• Eckart, C., Engler, H., Riether, C., Kolassa, S., Elbert, T., and Kolassa, I.T. 2009. No PTSD-related differences in diurnal cortisol profiles of genocide survivors.
  Psychoneuroendocrinology 34:523-531.
  PubMED

2008

• Pacheco-Lopez, G., Niemi, M.B., Engler, H., Engler, A., Riether, C., Doenlen, R., Espinosa, E., Oberbeck, R., and Schedlowski, M. 2008. Weakened [corrected] taste-LPS association during endotoxin tolerance.
  Physiology & behavior 93:261-266.
  PubMED

Reviews

• Riether, C., Schurch, C.M., and Ochsenbein, A.F. 2015. Regulation of hematopoietic and leukemic stem cells by the immune system.
  Cell death and differentiation 22:187-198.
  PubMED
• Schurch, C.M., Riether, C., and Ochsenbein, A.F. 2013. Interferons in hematopoiesis and leukemia.
  Oncoimmunology 2:e24572.
  PubMED
• Schurch, C.M., Riether, C., and Ochsenbein, A.F. 2013. Dendritic cell-based immunotherapy for myeloid leukemias.
  Frontiers in immunology 4:496.
  PubMED
• Riether, C., Schurch, C., and Ochsenbein, A.F. 2013. From "magic bullets" to specific cancer immunotherapy.
  Swiss medical weekly 143:w13734.
  PubMED
• Riether, C., Schurch, C., and Ochsenbein, A.F. 2012. Modulating CD27 signaling to treat cancer.
  Oncoimmunology 1:1604-1606.
  PubMED
• Riether, C., Doenlen, R., Pacheco-Lopez, G., Niemi, M.B., Engler, A., Engler, H., and Schedlowski, M. 2008. Behavioural conditioning of immune functions: how the central nervous system controls peripheral immune responses by evoking associative learning processes.
  Reviews in the neurosciences 19:1-17.
  PubMED

Book Chapters

• S. Hoepner, C. Riether and A.F. Ochsenbein. Principles of Immunobiology and Immunotherapy.
  ESMO Handbook of Translational Research (2015).
• M.B. Niemi, G. Pacheco-Lopez, H. Engler, C. Riether, R. Doenlen and M. Schedlowski. Neuro-immune associative learning.
  Handbook of Neurochemistry and Molecular Neurobiology (2008).